We have been gradually increasing the dose but it hasnt helped. My dogs have been throwing up since then and I could not for the life of me figure out why. My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. I had to put him laundry room for the night (no Carpet). Since the weather was turning cold, I stopped giving her the Simparica until spring. He never ever used to do this. Then a week later 2 more just 24 hours apart then a little over w week later she had 3 in 24 hours. Eat grass and vomit. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. Thank you all so much!!!! Today shes acting better, finally, but her back legs are still collapsing and she is weak. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. He had soft poop right after I give him the pill then got worse yellow diarrhea for about a week also vomiting he fine now they changed the medication. I gave them their 2nd dose, and 24 hours later, the Collie mix (Bella) was throwing up, lethargic, unsteady, drinking obsessively, panting, and could hardly walk. However, they are possible, so it is better to know they might happen. Just gave my baby her first dose. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water).. Is Simparica Trio killing dogs? However, doing nothing is better than giving her the Simparica. We are experiencing the same thing. I finally got him to eat some chicken and he threw that up 2 hours later. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. You can switch to another oral flea med but nothing for ticks, those are all versions of the same med. (Ours never did, she died 4 months later.) Mine has tremors once in a while and now I know why! She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. If you think that your dog has had an overdose of Simparica, contact your vet immediately to seek treatment. Im beyond heartbroken, shocked, and sad. I'll be calling them tomorrow. I am so upset - I gave it to him last week and he had an accident in the house. Then we seen an ad on tv for Simparica and it mentioned seizures as a side effect. I also lost my dog due to simparia Trio. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. So scary. Two weeks after first simparica dose.parasites gone. No simparica for them either! If she continues I will be going to the vet. This is lethal medication for dogs and should be taken off the market now. It could be a coincidence but seems too coincidental. I guarantee he will not take this trash again. I will never use this product again!!!!! Simparica Trio is intended for dogs and puppies weighing more than 2.8 pounds and older than 8 weeks of age. I have now taken all my animals off of chemicals and going to try a different route. Mine was given the medication 9 days ago. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. He protected our livestock from coyotes for many years and I took good care of him. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. Vet did all kinds of tests but said it couldnt be simparica. It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. Which Type of Dog Fence Is Right For Your Pet? He is a 89 lbs 5 y/o pitbull who has never had any issues before. Side effects include: vomiting, diarrhea, lethargy, anorexia, otitis externa (ear. Im so worried Ive lost him forever and hell never recover. The costs associated with these two products are roughly the same. Then I gave it to her again the 3rd month and the same thing happened. To make dosing easy, it's available for dogs in six sizes based on body weight range: Simparica Trio can be given to dogs with or without food. Trifexis is much safer and I really don't care about the ticks - I can pull those off. Related questions. Hoping that these side effects dont get worse and subside soon . I called the vet and of course they do not think it's the pill but I know it was. Omg Im feeling sick seeing all these bad comments. This can help with feelings of anxiety, stress, and fear." She has been diagnosed with thyroid problems and myocarditis. With Entyce she is getting her appetite back and seems a little better. My Lab mix has had 2 doses of this med. He is otherwise normal and healthy. On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. He first started with seizures and losing weight in June after giving him Simparica. He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. org to have this poison recalled. Our two year old dog took the same thing and thank god she has no symptoms. I returned that medicine back to the vet and bought Revolution! It has a good rating also 4.7 out of 5. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. Vet thought was inner ear infection now thinking otherwise. I hope the best for you and dog, I know its a tough time. My 3 other poodles unaffected. We tried stopping the simparica. If anyone has suggestions or knows how else I can help my little guy please let me know. Our 9 month 5lb Morkie was prescribed this garbage and we noticed the shakes, his lower lip quivering, and he looks around as if an invisible fly is flying around his head. Took a dose of simparica trio.second rose in second month.dog is having tremors. I'll continue to watch her. My poor baby! One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. Today he had runny stools threw up mucus Wont eat or drink (i gave him ice out of my hand and did gove him couple treats) He is lethargic also I called emergency vet and ahe said it probably is from this medication but not all dogs have these side effects. Not known if there be permanent after-effects. So, I gave it to him. The following morning he had another small seizure. PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. The .gov means its official.Federal government websites often end in .gov or .mil. The only thing we changed after his checkup if Feb. was his flea and tick treatment. She is still in the vet since 3am. I just want to cry! There is also a chance that hell need a surgery. Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. Yes Id like to know that answer myself. Vet said they dont think it has anything to do with the Simparica. Did you ever get to the bottom of redness in eyes? Gave Simparica to my dog yesterday. Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. Sold as 1 Month, 3 Month or 6 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. He is back to his old self now but we will never give him this medication again. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. Now do you get the connection? I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. She had some itching and a bit lethargic but is eating very well. Did you do this yourself or let the vet? What are the side effects of Simparica Trio for Dogs? This medication is generally well tolerated in most pets. What are the side effects of simparica trio for dogs? This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. A few months back he started with a morning vomiting always on his empty tummy. I gave my yellow Lab, Sophie, her first Simperica trio. But I have decided not to give the replacement pill today. Is it too late? I must admit that I am pretty nervous about it, but we shall see. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Oh Lord, back to finding another vet. He just isnt himself. All content contained in this article is sourced from public sources or the manufacturer. First time for this adverse reaction. The issues started within 24 hours of the dose and continue. Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. Never saw tremors before. Same here! A heartworm test may be necessary in about six months (that's how long it takes heartworm larvae to mature enough to show up on a test). She was terrified and we were too. He seems back to his normal self and playing with his toys, but we will not continue the following doses! RELATED: What You Need to Know About the Lyme Vaccine for Dogs. 8 months of prednisone and around the clock nursing care at home saved her life. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. Stay safe! 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