2013 Sep; 183(3):820-30. Altman Clinical and Translational Research Institute (ACTRI). 2003 Oct; 23(5):386-96. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. 1991 Oct; 14(4 Pt 1):740-2. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. J Biol Chem. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. PLoS One. Nucl Med Biol. Hepatol Commun. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Am J Epidemiol. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. 2000 Jul; 33(1):49-58. J Surg Res. 2021 08 01; 321(2):H435-H445. Transplantation. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. 2006 Aug; 116(8):2058-9. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. 2005 Sep; 230(8):573-86. 2019 07 23; 116(30):15184-15193. Gastroenterology. 1999 Jun; 19(6):4334-42. New functions for the aryl hydrocarbon receptor. Mol Cell Biol. PLoS One. J Trauma. Deletion of the ferrochelatase gene in a patient with protoporphyria. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 1990 Nov; 26(11):1011-23. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. 2012 Sep; 56(3):922-32. Gastroenterology. 2001 Dec; 281(6):G1357-68. J Immunol. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Proud to be part of UC San Diego and UC San Diego Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. 2004 Aug 01; 173(3):1561-70. Mol Cell Biol. Int J Biochem Cell Biol. 2014 Jun 10; 20(17):2854-72. Joint statement on missions and submissions of papers to AGA journals. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. 1998 10; 275(4):C1058-66. Exp Biol Med (Maywood). J Biol Chem. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. J Clin Invest. 1999 Sep 15; 163(6):3474-83. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. 2000 Aug; 119(2):446-60. Blood. Am J Physiol Cell Physiol. 2011 Jun; 31(3):521-32. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. DNA Cell Biol. Am J Clin Nutr. 2000 Apr 21; 275(16):11814-23. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. 1998 Aug; 115(2):443-51. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Dig Dis. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. Gastroenterology. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Gastroenterology. 2001 Jan; 33(1):81-90. Amyotroph Lateral Scler Frontotemporal Degener. Hepatol Res. 2008 Jul; 48(1):322-35. Nat Rev Gastroenterol Hepatol. Hepatology. 2001 Apr; 120(5):1251-62. Front Physiol. J Cell Biol. 2015; 10(7):e0129743. TLR4 enhances TGF-beta signaling and hepatic fibrosis. 2007 Nov; 46(5):1443-52. 1990 Apr; 7(2):105-15. Circ Res. Hepatology. 1999 Jul; 5(4):282-93. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. 2014 Jan; 59(1):19-20. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. 2017 Jun 16; 7:314-323. 2007 Aug; 22(8):1256-64. Front Physiol. Gastroenterology. Blood. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. WebDavid Brenner. 1991 Mar; 5(3):275-81. 2019 09; 71(3):573-585. 2007 Aug; 47(2):307-9. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. 2011 Apr; 25(2):305-17. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Immunol. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Mechanisms of fibrogenesis. Am J Hum Genet. Awareness, treatment, and control of vascular risk factors among stroke survivors. 2000 Dec; 32(6):1272-9. Involvement of death receptor-related signaling pathways. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Am J Physiol Gastrointest Liver Physiol. Proc Natl Acad Sci U S A. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Hepatology. 1986 Mar; 83(6):1762-6. Am J Physiol. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Transplantation. Cell Metab. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. 2000 Jan; 118(1):90-100. 2010 Jul; 139(1):323-34.e7. 2001 Jul; 34(1):89-100. A logical approach to the patient with jaundice. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. Nat Commun. J Immunol. 2005 Feb; 115(2):209-18. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. 1997 Sep; 17(9):5201-9. 1994 Dec; 124(6):755-60. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. 1990 Dec; 9(10):777-81. J Clin Invest. 1995 Sep; 9(9):1157-65. 2011 Jan; 53(1):96-105. 2014 Oct 28; 83(18):1653-60. 2018 09; 68(3):1070-1086. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Semin Liver Dis. 2014 Jul; 124(7):2921-34. Exercise training attenuates age-associated diastolic dysfunction in rats. Gastroenterol Hepatol (N Y). 1999 Mar; 15(2):103-7. Hepatology. 2002 May 17; 277(20):18229-37. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Hepatology. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. 2019 11 05; 30(5):850-852. 2001 Dec; 35(6):749-55. 2000; 35 Suppl 12:80-3. 2008 Dec; 173(6):1617-27. Fibrogenesis of parenchymal organs. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. 2003 Jan 10; 278(2):927-33. Am J Physiol Gastrointest Liver Physiol. J Immunol. 2016 08; 65(2):369-76. Toxicol Sci. 1998 Jan 01; 160(1):410-8. Stroke. Hepatology. Aliment Pharmacol Ther. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Hepatology. 2010; 2010:362847. 2019 01; 17(2):218-230. 2022 Mar; 1(1):pgac006. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. J Clin Invest. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Dig Dis Sci. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. In this role, he leads the School of Semin Liver Dis. Integr Biol (Camb). 1999 Oct; 18(10):751-61. 2011 Apr; 25(4):1133-44. 1989 Sep; 30(9):1220-4. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. Clin Gastroenterol Hepatol. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. 2008 Jul; 255(7):993-1000. UCSD Profiles is managed by the UC San Diego 2006 Jul; 37(7):1691-6. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Gastroenterology. 2005 Apr 08; 280(14):13374-82. 2000; 32(1 Suppl):32-8. J Clin Invest. 1997 May; 272(5 Pt 1):G943-53. J Bioenerg Biomembr. 2000 Jun 01; 95(11):3568-77. 2006 Sep; 131(3):957-60. Studies with human cultured skin fibroblasts. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. Expression of human immunodeficiency virus-1 in human colonic cells. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Hepatology. Promising Therapy Candidates for Liver Fibrosis. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Nat Commun. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. Hepatology. 1993 Sep; 92(3):1336-48. What's new in liver fibrosis? 2009 Jan 16; 378(3):348-53. Hepatology. Gastroenterology. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 1996 Feb; 23(2):379-80. La Jolla groups issue letter on city parks master plan. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 1994 Sep; 14(9):5950-60. Hepatology. 2014 Apr 29; 63(16):1626-33. 2002 Aug 15; 100(4):1470-7. The origin of myofibroblasts in liver fibrosis. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. 2015 Nov-Dec; 49 Suppl 1:S25-7. J Clin Invest. I. TNF-induced liver injury. To return to the graph. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Aliment Pharmacol Ther. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. 2010 Sep; 139(3):987-98. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. Cell Mol Gastroenterol Hepatol. Am J Physiol. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 2000 Dec; 32(6):1255-64. 2008 Feb; 25(2):249-58. 2006 Aug; 44(2):420-9. 2003 Jan 01; 8:d69-77. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. 2003 May; 73(1):44-52. Activation of activating protein 1 during hepatic acute phase response. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. WebBrenners new job suits his eclecticism. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Hepatol. Hepatology. 2004 Nov; 40(5):1106-15. JCI Insight. 2016 Mar; 13(3):126-8. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Compr Ther. 2003 Feb; 124(2):445-58. Am J Physiol. Reversibility of liver fibrosis. Hepatology. Hepatology. Biotechniques. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. J Clin Invest. Aliment Pharmacol Ther. J Biol Chem. 1999 Mar; 31(2):173-9. Am J Physiol. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER 2003 Feb; 37(2):267-76. Gastroenterology. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. 2012 Nov; 143(5):1330-1340.e1. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. 1999 Apr 15; 162(8):4447-54. 2019 02 04; 216(2):267-278. Mol Cell Biol. Gastroenterology. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Am J Physiol. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Int Psychogeriatr. 1998 04; 274(4):G669-76. Fibrogenesis Tissue Repair. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. 1998 Sep; 13 Suppl:S39-50. J Gastroenterol. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Am J Physiol Cell Physiol. Gut. 2019 07; 70(1):127-141. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. 2005 May; 41(5):1046-55. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. 2003 May; 37(5):1043-55. Mol Pharmacol. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Signal transduction during liver regeneration. Proc Natl Acad Sci U S A. Role of Gut Microbiota in Liver Disease. Proc Am Thorac Soc. 2011 Jul; 41(7):683-6. Surgery. J Gastroenterol. 2018 09; 68(3):918-932. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Mitogens and hepatocyte growth control in vivo and in vitro. Front Biosci. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. 2012 Dec; 56(6):2316-27. Dig Dis. 2006 Apr; 12(4):550-9. Hepatology. In Vitro Cell Dev Biol. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. 1994 Oct 21; 269(42):26396-401. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Human hepatic stellate cell isolation and characterization. 2021; 16(12):e0260721. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Modulation of constitutive collagen gene expression by lipid peroxidation. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Hepatobiliary Surg Nutr. People who share similar concepts with this person. 2021 09; 191(9):1564-1579. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. 2021; 8:790032. J Biol Chem. Mol Cell Biol. 2009; 44 Suppl 19:1-7. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. J Hum Nutr Diet. Proc Natl Acad Sci U S A. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Gastroenterology. 2000 Jul; 279(1):G100-6. 2005 Jun 10; 280(23):21763-72. 2012 Nov; 122(11):4280-2. 2002 Sep; 123(3):877-8. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. 1994 Oct; 267(4 Pt 1):G552-61. 2003 Apr; 38(4):468-75. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. 2000 Jan; 48(1):39-44. 2002 Mar; 82(3):323-33. Interactions between the intestinal microbiome and liver diseases. 1992 Jun; 50(6):1203-10. Aliment Pharmacol Ther. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. J Clin Invest. Allergy. 2007 Dec 07; 249(3):518-31. 2013 Aug; 20(8):1116-23. 1997 May; 25(5):1128-35. Introducing PNAS Nexus. Molecular and cellular biology of the small intestine. A method for in vitro DNase I footprinting analysis on supercoiled templates. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. Hepatology. 2020 05; 158(6):1728-1744.e14. Liver Transpl. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. 2011 Jan 04; 108(1):308-13. Am J Physiol. Am J Gastroenterol. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. 2018 12; 15(12):785. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2009 Apr; 136(4):1423-34. Hepatology. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. 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